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Abnormal soft tissue (tumor) also extends posteriorly at this T1-weighted scan that were included in a prior radiation port, due level, producing mild canal compromise and cord compression. The ill-defined, mild enhancement of T8 vertebral body height is consistent with an additional compres- within L2 is of unknown etiology, although radiation necrosis is a sion fracture. In this instance, an irregular low signal intensity band within the inferior half of T8 suggests a distinct fracture and thus os- teoporosis, without a definite metastatic focus identified. Treat- ence of a paraspinal mass, involvement of the pedicle or ment for this entity is typically conservative. Coexisting Diffuse Marrow Disease healed benign compression fractures and focal retropul- sion (superiorly or inferiorly) favor a benign compression Diffuse marrow low signal intensity on T1-weighted scans fracture. Marrow reconversion (myeloid hyperplasia) is an pathogenesis a matter of debate (in terms of a reactive versus additional cause, and occurs with severe chronic anemia a neoplastic process), usually affecting children. The mani- (specifically sickle cell disease and thalassemia) as well as festations of this disease range from isolated bone lesions treatment with granulocyte macrophage colony stimulat- to multisystem involvement, with the classic appearance ing factor during chemotherapy. Lymphoma, leukemia, and myeloma may all present with diffuse mar- row infiltration, and thus uniform abnormal low signal in- tensity marrow on T1-weighted scans (isointense to the intervertebral disk) (Fig. In this young male patient, there is near body and the intervertebral disk on T1-weighted scans. In the spine, this is a very character- vertebral marrow, when diffuse, can be easily overlooked. However, within this category of all occur with lymphoma, and simultaneous involvement disease (and, as emphasized multiple times in this section), of two or three regions is not uncommon. It is essential to evaluate the relative sig- nal intensity of the vertebral bodies and the intervertebral disks on T1-weighted scans on every acquired spine exam. Dif- fuse loss of the normal higher marrow sig- nal intensity (when compared to the disk space) is indicative of either a generalized marrow disorder or a very active marrow. Myeloma, lymphoma, and leukemia can all present in this fashion, with the appear- ance nonspecific in terms of etiology.

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Hanson, 39 years: Gold salts may cause nephropathy; see also anal- Testing of new drugs on animals for reproductive effects gesic nephropathy (p.

Konrad, 60 years: Adjuvant radiation to the primary site then referred to a medical oncologist for considera- should be strongly considered in patients in whom tion of adjuvant chemotherapy.

Ernesto, 31 years: In advanced known to undergo malignant transformation, teratomas that cases, modified exenteration of the orbital contents may still are confined to the orbit are generally benign.

Emet, 23 years: Areas of consolidation are seen on a plain flm; however, radiographic changes of a chest infection may lag behind in time with the clinical fndings.

Rathgar, 22 years: Special problems with antimicrobial drugs: resistance; In 1928, Fleming3 accidentally rediscovered the long- • superinfection; masking of infections.

Corwyn, 32 years: Other frequently encountered anomalies include: short broad hands with prominent fnger pads, partial syndac- tyly or mild interdigital webbing (complete and incomplete simple syndactyly) of the digits, small fnger clinodactyly, typical cleft hand, single transverse simian crease, and broad Aarskog Syndrome 403 Fig.

Murak, 58 years: Higher doses activity (or increase in glutamate) elicits arousal, anxiety, of longer-acting benzodiazepines partially suppress slow restlessness, insomnia and exaggerated reactivity.

Gnar, 36 years: Medial branch blocks are specific for radiofrequency lesions as a treatment for cervicogenic headache the diagnosis of cervical zygapophyseal joint pain.

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